The HIV human
immunodeficiency virus is a virus that attacks cells that help the body fight
infection, making a person more vulnerable to other infections and diseases.
It is spread by contact with certain bodily fluids of a person with HIV, most commonly during sex with a
condom or sex without a condom
HIV can lead to the disease AIDS (acquired immunodeficiency syndrome).
The human body can’t get rid of HIV and no effective HIV cure exists. So, once you have HIV, you have
it for life.
In addition, there are effective methods to prevent getting HIV through sex or drug use, including pre- exposure prophylaxis (Prep) and post-exposure
prophylaxis (PEP).
The
human immunodeficiency viruses (HIV) are two species of Lent virus (a subgroup
of retrovirus) that infect humans.
Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune
system allows life-threatening opportunistic infections and cancers to thrive.
The average survival time after infection with HIV is estimated to be 9 to 11
years.
In most
cases, HIV is a sexually transmitted infection and occurs by contact with or
transfer of blood, pre-ejaculate, semen, and vaginal fluids.
Non-sexual
transmission can occur from an infected mother to her infant during pregnancy,
during childbirth by exposure to her blood or vaginal fluid, and through breast
milk.
Within these bodily fluids, HIV is present as both free virus particles and virus within infected the vital immune cells in the human
immune system, such as helper T cells (specifically CD4+ T cells), macrophages,
and dendritic cells.
HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells, apoptosis of
uninfected bystander cells, direct viral killing of infected cells, and killing
of infected CD4+ T cells by CD8+ cytotoxic lymphocytes that recognize infected
cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more
susceptible to opportunistic infections, leading to the development of AIDS.
WHAT DAMAGE THE INFECTION CAN CAUSE
The different damage the HIV infection can cause are called:
Pneumocystis Pneumonia (PCP).
This fungal infection can cause severe illness.
PCP is still the most
common cause of pneumonia in people infected with HIV.
Candidiasis (Thrush).
Candidiasis
is a common HIV-related infection. It causes inflammation and a thick, white
coating on your mouth, tongue, esophagus or vagina.
Tuberculosis (TB).
TB is a common opportunistic infection associated with HIV. Worldwide, TB is a leading cause of death
among people with AIDS.
Cytomegalovirus.
This common herpes virus is transmitted in body fluids such as saliva, blood, urine, semen and breast
milk. A healthy immune system inactivates the virus, and it remains dormant in
your body.
If your immune system weakens, the virus resurfaces, can cause damage to your eyes, digestive tract,
Lungs or other organs.
Cryptococcal Meningitis.
Meningitis
is an inflammation of the membranes and fluid surrounding your brain and spinal
cord (meninges).
Cryptococcal meningitis is a common central nervous system infection associated with HIV, caused by a fungus found in soil.
-Toxoplasmosis.
This potentially deadly infection is caused by Toxoplasma gondii, a parasite
spread primarily by cats.
Infected cats pass the parasites in their stools, which may then spread to other animals and humans. Toxoplasmosis can cause heart disease, and seizures occur when it spreads to the brain.
WHAT ARE THE SYMPTOMS OF HIV INFECTIONS
The symptoms of HIV and AIDS vary, depending on the phase of infection.
Primary infection (Acute HIV)
Some people infected by
HIV develop a flu-like illness within 2 to 4 weeks
Most
people experience a short flu-like illness 2 to 6 weeks after HIV infection
after the virus enters the body which lasts for a week or 2.
After these symptoms disappear, HIV may not cause any symptoms for many years, although the virus continues to damage your immune
system.
This means many people with HIV do not know they're infected as they're at particularly high risk this illness, known as primary (acute) HIV infection,
has
Possible signs and symptoms include:
-Fever
-Headache
-Muscle aches and joint pain
-Rash
-Sore throat and painful mouth sores
-Swollen lymph glands, mainly
on the neck
-Diarrhea
-Weight loss
-Cough
-Night sweats
- Persistent, unexplained fatigue
-Swollen lymph glands
-Oral yeast infection (thrush)
-Shingles (herpes zoster)
-Pneumonia
-Progression to AIDS
-Sweats
-Chills
-Persistent white
spots or unusual lesions on
your tongue or in your mouth
-Weakness
-Weight loss
These
symptoms can be so mild that you might not even notice them. However, the
amount of virus in your bloodstream is quite high at this time. As a result,
the infection spreads more easily during primary infection than during the next
stage.
Clinical latent infection (Chronic HIV)
In this stage of infection, HIV is still present in the body and in white blood cells. However, many people
may not have any symptoms or infections during this time.
This stage can last
for many years.
Some people develop more severe disease much sooner.
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